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KMID : 0613820210310010047
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Journal of Life Science
2021 Volume.31 No. 1 p.47 ~ p.51
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Inhibition of Tyrosinase by Metabolites Originating from Thrichoderma atroviride
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Kang Dong-Woo
Kim Kyu-Min
Kim Ye-Seong
Seo Yu-Jin
Song Da-Yeong
Oh Da-Yun
Choi Si-On
Hwang Ju-Hyeon
Kim Sam-Woong
Bang Kyu-Ho
Gal Sang-Wan
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Abstract
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In today’s society, functional whitening cosmetics are important to beauty. Fungi are known to produce a variety of whitening-related metabolites. In this study, we searched for tyrosinase inhibitors with metabolic products derived from Trichoderma atroviride supernatant in order to apply a material for whitening functional cosmetics. In addition, the inhibitory effect was compared to arbutin, which has already been approved as a whitening raw material by the Korea Ministry of Food and Drug Safety (KMFDS). The metabolites from the T. atroviride supernatant showed higher tyrosinase inhibitory activity than that of arbutin. Some of the tyrosinase inhibitors were stable to heat, whereas some were unstable. The heat unstable material was exhibited in the case of samples treated with little amounts, such as 0.02~0.2%. They were very unstable in acidic and alkali pHs, especially under acidic conditions. However, it was found that a weakly-acidic to neutral pH range was the optimal working pH, especially neutral pH. Since the activity of the inhibitory substances in the T. atroviride supernatant was maintained regardless of proteinase K treatment, it was assumed that the metabolites, but not the bioactive peptides, were involved in the activity. In summary, we propose that the metabolites derived from T. atroviride supernatant have strong potential as whitening raw material.
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KEYWORD
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Cosmetics, metabolite, Trichoderma atrovide, tyrosinase inhibitor, whitening raw material
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